How to track blood glucose from the CGM?

  • Sayantan Majumdar
  • Saurabh D. Kalamkar
  • Shashikant Dudhgaonkar
  • Saroj Ghaskadbi
  • Pranay Goel
Date: 3-2023
Organisation: Chellaram Diabetes Institute
Note: Presentation at the 7th International Diabetes Summit - 2023 (IDS), Pune
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Diabetes Mellitus (DM) is a metabolic disorder which affects a large percentage of the worlds population. Diagnosing DM is usually done using various metrics like HbA1c, fasting blood glucose concnetration (FBG), post-parandial blood glucose concnetration (PPBG), average blood glucose concentration (aBG), etc. A majority of these metrics are either derived from the blood glucose concentration (BG) or are proxies for the BG in some way. The recently developed continuous glucose monitoring (CGM) devices generally measure the interstitial fluid glucose concentration (ISF) and provide a finite sequence of the measurements. It would be useful if the ISF-BG dynamics could be exploited to obtain an estimate of the continuous BG from the CGM trace. We have developed a method based on trajectory optimization that provides an estimate of the continuous BG from the discrete ISF measurements provided by the CGM devices.